Authors: Janella Cristin S. Mercado-Garcia, MD, Ma. Corazon Iniego, MD, Vilma O. Pelino, MD, FPDS, Elizabeth P. Prieto, MD, FPDS
Introduction: Darier’s Disease is a rare autosomal dominant genetic disorder characterized by predominantly scaly or keratotic papules distributed on the seborrheic areas of the body, with nail splitting, palmar pits and a malodorous scent. It is a chronic disease with a prevalence of 1-4 out of 100,000 people. Abnormality in the gene ATP2A2 that codes for the Sarcoendoplasmic Reticulum Calcium ATP-ase pump is implicated in the disease.
Case Summary: This is a rare case of a 32-year-old Filipino female who presents with a 26-year history of pruritic, keratotic papules and plaques on the seborrheic areas of her body, such as the face, chest, back, including her upper and lower extremities. The patient had dystrophic nails, and a characteristic malodorous scent. Skin punch biopsy revealed Darier’s Disease. Patient was put on topical medications such as Urea 10% lotion and Triamcinolone cream. Fractional CO2 laser, an ablative treatment that has been used in some case studies as a novel treatment for Darier’s Disease was done on the patient for 2 sessions, resulting into a reported 70% improvement of lesions.
Conclusion: Darier’s Disease is a chronic condition with frequent exacerbations. Sun exposure, heat, and sweat can worsen the manifestation of the disease. While there is no cure for Darier’s Disease, skin appearance can be drastically improved. Treatment of choice includes oral acitretin or isotretinoin. Localized lesions can be improved with topical corticosteroids and topical retinoids. Novel treatments include laser ablation, such as the Fractional CO2 laser which has been on our patient.
darier’s disease, darier-white disease, keratosis follicularis, fractional CO2 laser
Authors: Katrina Carmela M. Belen, MD, DPDS, Jasmin J.Jamora, MD, FPDS , Ma. Cecilia P. Ingente MD, DPDSAbstractBackground: Dermoscopy, a non-invasive diagnostic tool, has been proven to improve the diagnostic accuracy of vascular tumors since it can aid in...
A randomized, double-blind, comparative study on the safety and efficacy of virgin coconut (Cocos nucifera l.) oil against 1% hydrocortisone lotion as an anti-inflammatory and antipruritic preparation for mosquito reactions
Authors: Uy, Veronica S, MD; Gracia B. Teodosio, MD, FPDS; Ma. Teresita G. Gabriel, MD, FPDS; Mary Catherine T. Galang, MD; Mohammad Yoga A. Waskito, MD; Johannes F. Dayrit, MD, FPDS Abstract Background: Virgin coconut oil (VCO) has been reported...
Primary Cutaneous Anaplastic Large Cell Lymphoma (PC-ALCL) is a rare Non-Hodgkin lymphoma (NHL) representing approximately 9% of all cutaneous lymphomas.3 It usually manifests as a slow-growing, solitary tumor which has a tendency to regress spontaneously. However, metastasis is reported in 5-10% of cases.