(Last Updated On: October 30, 2018)

Authors: Patricia V. Cabral, MD

Abstract

Introduction: Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap is an acute life-threatening mucocutaneous reaction characterized by extensive necrosis and detachment of the epidermis, usually with drugs as the most important etiologic factor. We present a case of Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap in a Filipino female treated with a combination of Intravenous Immunoglobulin and Corticosteroids.

Case summary: A 51-year-old Filipino female, known case of Tic Disorder, was prescribed Carbamazepine for the first time. She presented with painful erosions on the lips with dysphagia and generalized pruritic and tender erythematous plaques, topped with flaccid vesicles, bullae and erosions. She was admitted as a case of Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap and upon presentation, underwent combination treatment of Intravenous Immunoglobulin and Corticosteroids.

Conclusion: Despite some studies showing the benefit of combination treatment of Intravenous Immunoglobulin and Corticosteroids, in our case, there was still noted progression of lesions. Despite eventual recovery, duration of hospital stay was not shortened and due to the cost of Intravenous Immunoglobulin, we would recommend alternative treatments for Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap.

 

Citation

 

Keywords

stevens johnson syndrome, toxic epidermal necrolysis, corticosteroids, intravenous immunoglobulin

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