(Last Updated On: May 4, 2019)

Authors: Ma. Vinna N. Crisostomo, MD, Mary Jo Kristine S. Bunagan, MD, FPDS


A 23-year-old male diagnosed with Hansen’s disease, BBBL, was started on multi-drug therapy (MDT). On his 6th month of therapy, he was started on prednisone 40mg/day for management of type 2 lepra reaction. The dose
of prednisone was decreased by 5 mg every two weeks. On the 12th month of therapy, the dose of prednisone was decreased to 10 mg/day. However, the presence of new generalized papules associated with fever and arthralgia was noted. As an attending physician, one would want to add a steroid-sparing
agent together with prednisone that would help control the lepra reaction of this patient to prevent the consequences of long-term steroid therapy



Crisostomo MV, Bunagan MJ. A critical appraisal of an article on therapy: Safety and efficacy of oral fusidic acid as a steroid-sparing agent in the treatment of lepra reactions: an assessor-blinded, randomized controlled clinical trial. J Phil dermatol Soc. 2018; 27(1): 87-9.



Hanses, Disease, BBBL, Fusidic Acid

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5. Gabriel MT, Hipolito RH, Chan GP, Salvador LR et al. Safety and efficacy of oral fusidic acid as a steroid-sparing agent in the treatment of lepra reactions:

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