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Authors: Michael Vince D. Busa, MD, DPDS, Janice Natasha C. Ng, MD, DPDS, Maricarr Pamela M. Lacuesta-Gutierrez, MD, FPDS

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Background: Acne vulgaris is a common dermatologic disorder caused by follicular colonization of Propionibacterium acnes leading to inflammation. Enzymatic virgin coconut oil monoglyceride has been shown to have anti-inflammatory effects and antimicrobial activity against Propionibacterium acnes.

Objectives: To compare the efficacy and safety of enzymatic virgin coconut oil monoglyceride (EVCO) 2% cream versus benzoyl peroxide (BPO) 5% cream in the treatment of mild to moderate acne vulgaris.

Methods: 100 participants with mild to moderate acne or a rating of 2 or 3 in the Investigator’s Global Assessment (IGA) for acne were randomized to receive either EVCO 2% cream or BPO 5% cream applied on the face twice daily over an 8-week period. Primary outcomes measured in the study were clearance rate graded as “clear” or “almost clear” (rating of 0 or 1) based on the IGA and adverse reaction rate.

Results: At week 8, the clearance rate was achieved in 56% (28/50) of participants in the BPO group and 46% (23/50) in the EVCO group. The difference between the two groups was not statistically significant (p=0.319). Adverse reactions observed in the BPO group were erythema (16%), pruritus (14%), scaling (12%), dryness (6%) and burning/stinging (6%) and while in the EVCO group only burning/stinging (2%) was noted; however, this was not statistically significant (p=0.1806).

Conclusion: EVCO 2% cream is an efficacious and safe alternative treatment for acne vulgaris



Busa MV, Ng JN, Lacuesta-Gutierrez MP. A prospective, randomized, double-blind, comparative study on the efficacy and safety of 2% enzymatic virgin coconut oil monoglyceride cream versus 5% benzoyl peroxide cream in the treatment of mild to moderate acne vulgaris. J Phil Dermatol Soc. 2018; 27(2): 18-30.



acne vulgaris, enzymatic virgin coconut oil, benzoyl peroxide

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