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A randomized, comparative study on the efficacy and safety of mangosteen 1% extract gel versus benzoyl peroxide 5% gel in the treatment of mild to moderate acne vulgaris

Janice Natasha C. Ng, MD, FPDS, Maria Vinna N. Crisostomo, MD, DPDS, Margaret Stephanie L. Jimenez, MD, DPDS, Mary Jo Kristine S. Bunagan, MD, FPDS



Acne vulgaris is a common dermatologic disorder caused by follicular epidermal hyperproliferation, excess sebum production, inflammation, and Cutibacterium acnes (C. acnes). The mangosteen fruit rind contains large amount of xanthones, which has high antimicrobial activity against C. acnes.



To compare the efficacy and safety of mangosteen 1% extract gel versus benzoyl peroxide (BPO) 5% gel in the treatment of mild to moderate acne vulgaris.



A total of 60 participants with mild to moderate acne or a rating of 2 or 3 in the Investigator’s Global Assessment (IGA) for acne were randomized to receive either mangosteen 1% extract gel or BPO 5% gel applied on the face twice daily over an 8-week period. Primary outcomes measured in the study were clinical remission graded as “clear” or “almost clear” (rating of 0 or 1) based on the IGA and any adverse reaction.



At week 8, 73% (23/30) in the BPO group and 53% (16/30) in the mangosteen group achieved clinical remission, although the difference between the two groups were not statistically significant (P = 0.108). In the BPO group, 4% (1/27) had a weak reaction during the 2nd follow up, while in the mangosteen group all participants did not have any reactions; however, this was not statistically significant (P = 0.627).



Mangosteen 1% extract gel is a safe and effective alternative treatment for mild to moderate acne vulgaris.


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A randomized, comparative study on the efficacy and safety of mangosteen 1% extract gel versus benzoyl peroxide 5% gel in the treatment of mild to moderate acne vulgaris