Janice Natasha C. Ng, MD, FPDS,
Maria Vinna N. Crisostomo, MD, DPDS,
Margaret Stephanie L. Jimenez, MD, DPDS,
Mary Jo Kristine S. Bunagan, MD, FPDS
INTRODUCTION : Acne vulgaris is a common dermatologic disorder caused by follicular epidermal hyperproliferation, excess se-bum production, inflammation, and Cutibacterium acnes (C. acnes). The mangosteen fruit rind contains large amount of xantho- nes, which has high antimicrobial activity against C. acnes.
OBJECTIVES : To compare the efficacy and safety of mangosteen 1% extract gel versus benzoyl peroxide (BPO) 5% gel in the treat- ment of mild to moderate acne vulgaris.
METHODS : A total of 60 participants with mild to moderate acne or a rating of 2 or 3 in the Investigator’s Global Assessment (IGA)
for acne were randomized to receive either mangosteen 1% extract gel or BPO 5% gel applied on the face twice daily over an
8-week period. Primary outcomes measured in the study were clinical remission graded as “clear” or “almost clear” (rating of 0 or
1) based on the IGA and any adverse reaction.
RESULTS : At week 8, 73% (23/30) in the BPO group and 53% (16/30) in the mangosteen group achieved clinical remission, although the difference between the two groups were not statistically significant (P = 0.108). In the BPO group, 4% (1/27) had a weak reac-tion during the 2nd follow up, while in the mangosteen group all participants did not have any reactions; however, this was not statistically significant (P = 0.627).
CONCLUSION : Mangosteen 1% extract gel is a safe and effective alternative treatment for mild to moderate acne vulgaris.
KEYWORDS : acne vulgaris, mangosteen extract, benzoyl peroxide
Authors: Katrina Carmela M. Belen, MD, DPDS, Jasmin J.Jamora, MD, FPDS , Ma. Cecilia P. Ingente MD, DPDSAbstractBackground: Dermoscopy, a non-invasive diagnostic tool, has been proven to improve the diagnostic accuracy of vascular tumors since it can aid in...
A randomized, double-blind, comparative study on the safety and efficacy of virgin coconut (Cocos nucifera l.) oil against 1% hydrocortisone lotion as an anti-inflammatory and antipruritic preparation for mosquito reactions
Authors: Uy, Veronica S, MD; Gracia B. Teodosio, MD, FPDS; Ma. Teresita G. Gabriel, MD, FPDS; Mary Catherine T. Galang, MD; Mohammad Yoga A. Waskito, MD; Johannes F. Dayrit, MD, FPDS Abstract Background: Virgin coconut oil (VCO) has been reported...
Primary Cutaneous Anaplastic Large Cell Lymphoma (PC-ALCL) is a rare Non-Hodgkin lymphoma (NHL) representing approximately 9% of all cutaneous lymphomas.3 It usually manifests as a slow-growing, solitary tumor which has a tendency to regress spontaneously. However, metastasis is reported in 5-10% of cases.