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A randomized, double-blind clinical trial on the efficacy and safety of turmeric 1% cream in the treatment of plaque-type psoriasis in adults


Authors: Bryan Edgar Guevara MD , Elisa Rae Coo MD , Mary Jo Christine Bunagan MD




Background: Turmeric demonstrated anti-inflammatory properties in laboratory and clinical studies that suggest its usefulness in psoriasis. This is the first randomized controlled trial comparing the efficacy and safety of turmeric 1% cream to clobetasol propionate 0.05% cream in the treatment of plaque-type psoriasis.

Objectives: To determine the efficacy and safety of turmeric 1% cream versus that of clobetasol propionate 0.05% cream in the treatment of plaque-type psoriasis.

Methods: This was a randomized, double-blind clinical trial to determine the proportion of patients with clinical remission. Secondary outcomes namely mean PASI and pruritus scores per visit, time to remission and incidence of adverse effects were also determined.

Results: Fifty-nine patients were randomized into two groups: a turmeric (n=30) and a clobetasol (n=29) group. After four weeks of treatment, there was no significant difference (p=0.36) in the proportions of patients with clinical remission in the turmeric group (5/20, 25%) and the clobetasol group (8/23, 35%) (RR 1.15, 95% CI 0.78-1.70). The average time to achieve clinical remission was 4 weeks in the turmeric group and 3.38 ± 1.06 weeks in the clobetasol group (p=0.07). There was no significant difference in post-treatment mean PASI scores in turmeric (8.77 ± 5.71) and clobetasol (7.26 ± 6.04) groups (p=0.40). Post-treatment mean pruritus scores in turmeric (6.9 ± 2.83) and clobetasol (5.83 ± 3.87) groups (p=0.30) were also statistically comparable. Two patients in the clobetasol group developed folliculitis.

Conclusion: Turmeric 1% cream demonstrated comparable efficacy and safety with clobetasol 0.05% cream in the treatment of mild to moderate plaque-type psoriasis.



 Guevara BEK, Coo ER, Bunagan MJ. A randomized, double-blind clinical trial on the efficacy and safety of turmeric 1% cream in the treatment of plaque-type psoriasis in adults. J Phil Dermatol Soc 2019, 28(1), 23-32


turmeric, psoriasis, herbal, Philippines

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A randomized, double-blind clinical trial on the efficacy and safety of turmeric 1% cream in the treatment of plaque-type psoriasis in adults