A randomized, double-blind, controlled trial on the antibacterial efficacy and safety of Moringa oleifera leaves Bar Soap and Moringa oleifera seed bar soap compared to Triclosan Against Staphylococcus aureus and Staphylococcus epidermidis

Authors: Carminda P. Rogacion, MD, Ma. Teresita G. Gabriel, MD, FPDS, Gracia B. Teodosio, MD,
FPDS, Marie Claudine Francesca Perlas, MD, Maria Isabel Belizario, MD

Abstract

Background: Staphylococcus aureus and Staphylococcus epidermidis are common pathogens that cause skin and soft tissue infections. Triclosan soaps are usually used to prevent contamination. We demonstrate the antibacterial efficacy and safety of 25% Moringa oleifera leaf extract (MOLE) bar soap, Moringa oleifera seed extract (MOSE) bar soap with 0.3% triclosan bar soap against Staphylococcus aureus and Staphylococcus epidermidis.

Objectives: To determine the safety and efficacy of 25% Moringa oleifera leaf extract (MOLE) bar soap and 25% Moringa oleifera seed extract (MOSE) bar soap against Staphylococcus aureus and Staphylococcus epidermidis compared to 0.3% triclosan bar soap.

Methods: A randomized, double-blind, controlled study of 90 subjects using 25% Moringa oleifera leaf extract (MOLE) bar soap, 25% Moringa oleifera seed extract (MOSE) bar soap, 0.3% triclosan bar soap. Colony growth of S. aureus and S. epidermidis before and after handwashing were compared. Wilcoxon signed rank test and Chi2 test were used for statistical analysis.

Results: 90 subjects (100%) completed the trial. There is no statistically significant difference on the reduction of bacterial colonies of S. aureus and S. epidermidis by 25% MOLE bar soap versus Triclosan bar soap (p values of 0.418 and 0.232, respectively). There is also no statistically significant difference on the reduction of bacterial colonies of S. aureus and S. epidermidis by 25% MOSE bar soap compared to Triclosan bar soap (p values of 0.440 and 0.654, respectively). No adverse events noted.

Conclusion: 25% MOLE bar soap and 25% MOSE bar soap are equally safe and effective as 0.3% triclosan bar soap against S. aureus and S. epidermidis.

 

Citation

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Keywords

Moringa oleifera, triclosan, Staphylococcus aureus, Staphylococcus epidermidis

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