(Last Updated On: October 29, 2018)

Authors: Fatima DC. Jacinto-Calimag, MD, Ma. Corazon A. Iniego, MD, Ma. Angela M. Lavadia, MD, FPDS, Elizabeth P. Prieto, MD, FPDS

Abstract

Background: Atopic Dermatitis is an emerging public health concern. Recently, several studies have explored the role of Vitamin D in atopic dermatitis. To date, there is no local study using Vitamin D supplementation as an adjunct in the treatment of atopic dermatitis.

Objective: To determine the efficacy of Vitamin D supplementation in improvement of the disease severity in atopic dermatitis patients.

Methods: This is a Randomized, double blind, placebo-controlled clinical trial. The participants are newly diagnosed atopic dermatitis patients aged 19 to 50 years old. Participants were randomly assigned to take either 1 capsule of oral Vitamin D supplement (2200 IU/capsule) or a comparable placebo capsule, once daily for 60 days. Vitamin D level and disease severity using SCORAD index was evaluated at the start and end of the study.

Results: The mean value of serum Vitamin D levels was deficient and comparable between the treatment and placebo group. The mean change in the serum Vitamin D levels of patients in the Treatment and Placebo group were 10.4 ng/mL ± 5.8 and -0.4 ng/mL ± 3.5, respectively. The mean change in the SCORAD index scores of patients in the Treatment and placebo group were -20.2 ± 20.6 and 2.2 ± 6.8, respectively. Result of the two-sample independent t-test showed that the mean change in the SCORAD index scores significantly varied according to treatment group (p<0.0001).

Conclusion: The results from this study indicate that vitamin D supplementation may ameliorate clinical signs of the disease and can be considered as a safe and well-tolerated form of therapy.

 

Citation

 

Keywords

Atopic dermatitis, Vitamin D, SCORAD index, t-test

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