(Last Updated On: October 29, 2018)

Authors: Fatima DC. Jacinto-Calimag, MD, Ma. Corazon A. Iniego, MD, Ma. Angela M. Lavadia, MD, FPDS, Elizabeth P. Prieto, MD, FPDS


Background: Atopic Dermatitis is an emerging public health concern. Recently, several studies have explored the role of Vitamin D in atopic dermatitis. To date, there is no local study using Vitamin D supplementation as an adjunct in the treatment of atopic dermatitis.

Objective: To determine the efficacy of Vitamin D supplementation in improvement of the disease severity in atopic dermatitis patients.

Methods: This is a Randomized, double blind, placebo-controlled clinical trial. The participants are newly diagnosed atopic dermatitis patients aged 19 to 50 years old. Participants were randomly assigned to take either 1 capsule of oral Vitamin D supplement (2200 IU/capsule) or a comparable placebo capsule, once daily for 60 days. Vitamin D level and disease severity using SCORAD index was evaluated at the start and end of the study.

Results: The mean value of serum Vitamin D levels was deficient and comparable between the treatment and placebo group. The mean change in the serum Vitamin D levels of patients in the Treatment and Placebo group were 10.4 ng/mL ± 5.8 and -0.4 ng/mL ± 3.5, respectively. The mean change in the SCORAD index scores of patients in the Treatment and placebo group were -20.2 ± 20.6 and 2.2 ± 6.8, respectively. Result of the two-sample independent t-test showed that the mean change in the SCORAD index scores significantly varied according to treatment group (p<0.0001).

Conclusion: The results from this study indicate that vitamin D supplementation may ameliorate clinical signs of the disease and can be considered as a safe and well-tolerated form of therapy.





Atopic dermatitis, Vitamin D, SCORAD index, t-test

More Articles

A randomized, double-blind, comparative study on the safety and efficacy of virgin coconut (Cocos nucifera l.) oil against 1% hydrocortisone lotion as an anti-inflammatory and antipruritic preparation for mosquito reactions

  Authors: Uy, Veronica S, MD; Gracia B. Teodosio, MD, FPDS; Ma. Teresita G. Gabriel, MD, FPDS; Mary Catherine T. Galang, MD; Mohammad Yoga A. Waskito, MD; Johannes F. Dayrit, MD, FPDS     Abstract Background: Virgin coconut oil (VCO) has been reported...

read more