(Last Updated On: May 18, 2021)

Anna Cecilia Francesca I. Alvarez
Jose Giovanni E. Dimayuga

Abstract

Background: Carica papaya latex has been found to have antifungal properties rendering an alternative treatment for fungal infections, i.e. pityriasis versicolor. It has remarkable mycelial inhibition, and static effect on fungal growth in cultures. Its keratolytic effect can remove diseased skin cells, and enhance drug penetration. Moreover, it is organic, locally available, and relatively inexpensive.

Objective: To compare the efficacy and safety of 1.5% Carica papaya latex cream vs. 2% ketoconazole cream in the treatment of pityriasis versicolor among Filipinos.

Methods: A single-center, parallel group, triple-blind, randomized controlled trial in the Dermatology out-patient clinic of Makati Medical Center was conducted. Sixty-four patients with pityriasis versicolor were randomly allocated to the two treatment groups, and received either 1.5% Carica papaya latex cream or 2% ketoconazole cream that they used twice daily for four weeks or until cured. The participants, researcher, and assessor were blinded to the treatment assignments. Therapeutic response was assessed at weeks 1, 2, 3 and 4 based on clinical and mycologic cure. Adverse events were identified. Patients’ assessment of their improvement was done at the end of the treatment.

Results: All 64 subjects in both treatment groups (100% in the Carica papaya and 100% in the ketoconazole group) achieved clinical and mycologic cure within the four-week study period. The adverse reactions noted (pruritus and erythema for Carica papaya latex cream, and pruritus for ketoconazole cream) were mild, did not cause disruption of daily activities, and spontaneously resolved.

Conclusion: 1.5% Carica papaya latex cream is an effective and safe alternative treatment to the first line therapy, ketoconazole cream, for pityriasis versicolor.

 

Keywords: Carica papaya, pityriasis/tinea versicolor

Citation

 

 

 

  1. Morais P, Cunha M, Frota M. Clinical aspects of patients with pityriasis versicolor seen at a referral center for tropical dermatology in Manaus, Amazonas, Brazil. An Bras Dermatol. 2010; 85(6):797-803. DOI: 10.1590/s0365-05962010000600004.
  2. Handog E, Dayrit J. Mycology in the Philippines, revisited. Jpn. J. Med. Mycol. 2005; 46(2):71-76. DOI: 10.3314/jjmm.46.71.
  3. Sharma R, Sharma G, Sharma M. Comparative antifungal study of essential oil with allopathic drugs against Malassezia furfur. International Journal of Pharmaceutical & Biological Archives 2012; 3(1):89-93.
  4. Bolognia, J, Jorizzo, J, Schaffer Dermatology. 3rd ed. USA: Elsevier Saunders; 2012.
  5. Rai M, Wankhade S. Tinea versicolor – an epidemiology. Journal of Microbial & Biochemical Technology. 2009; 1(1):51-56. DOI:10.4172/1948-5948.1000010.
  6. Muzzafar F, Ejaz A, Mahmood K. Determination of cost effective topical therapy for pityriasis versicolor. Journal of Pakistan Association of Dermatologists. 2008; 18(3):159-164.
  7. Amri E, Mamboya Papain, a plant enzyme of biological importance: a review. American Journal of Biochemistry and Biotechnology, 2012; 8(2):99- 104. DOI: https://doi.org/10.3844/ajbbsp.2012.99.104.
  8. Krishna K, Paridhavi M, Patel J. Review on nutritional, medicinal, and pharmacological properties of papaya. Natural Product Radiance. 2008; 7(4):364-373.
  9. Chukwuemeka O, Anthonia A. Antifungal effects of pawpaw seed extracts and papain on post-harvest Carica papaya L. fruit rot. African Journal of Agricultural Research. June 2010; 5(12):1531-1535. DOI: 10.5897/AJAR.9000056.
  10. Buensalido J, Dimagiba The efficacy and safety of Carica papaya latex 1.5% cream compared to 2% ketoconazole cream and a paraffin-based vehicle in the treatment of tinea corporis: a randomized, double blind controlled trial. J Phil Dermatol Soc. May 2011: 20(1):15-20.
  11. Kang S, Amagai M, Bruckner A, Enk A, Margolis D, McMichael A, et Fitzpatrick’s Dermatology in General Medicine. 9th ed. NY: The McGraw-Hill Companies, Inc.; 2012.
  12. Bakr E, Abdo H, Abd-Elaziz H, Abd-Elrazek H, Amer Adapalene gel 0.1% vs ketoconazole cream 2% and their combination in treatment of pityriasis versicolor: A randomized clinical study. Dermatol Ther. June 2020; 33(3):e13319. DOI: 10.1111/dth.13319.
  13. Indoor Air Quality Association, Inc. Recommended Guidelines for Indoor Environments: IAQA 01-2000. Connecticut: Indoor Air Quality Association; 2000.

More Articles

A randomized, double-blind, comparative study on the safety and efficacy of virgin coconut (Cocos nucifera l.) oil against 1% hydrocortisone lotion as an anti-inflammatory and antipruritic preparation for mosquito reactions

  Authors: Uy, Veronica S, MD; Gracia B. Teodosio, MD, FPDS; Ma. Teresita G. Gabriel, MD, FPDS; Mary Catherine T. Galang, MD; Mohammad Yoga A. Waskito, MD; Johannes F. Dayrit, MD, FPDS     Abstract Background: Virgin coconut oil (VCO) has been reported...

read more