A clinical trial is a planned experiment designed to evaluate the benefits of a treatment for a specific medical condition. A welldesigned clinical trial is the most rigorous research design for evaluating treatments. However, there several situations where it is neither possible nor ethical to conduct a clinical trial. In these situations, observational studies may be more appropriate in evaluating possible associations between a factor of interest (not necessarily treatment) and a particular disease or outcome. In observational study designs, the investigator has no control over the exposure of individuals. Study participants are observed and data are collected but nothing is done to influence either the exposure or the course of events. We will consider three main observational study designs in this article.
Evangelista-Huber M. An introduction to observational studies. J Phil Dermatol Soc. 2018; 27(2): 63-5.
concepts of observational study, observational studies, clinical trial
Authors: Katrina Carmela M. Belen, MD, DPDS, Jasmin J.Jamora, MD, FPDS , Ma. Cecilia P. Ingente MD, DPDSAbstractBackground: Dermoscopy, a non-invasive diagnostic tool, has been proven to improve the diagnostic accuracy of vascular tumors since it can aid in...
A randomized, double-blind, comparative study on the safety and efficacy of virgin coconut (Cocos nucifera l.) oil against 1% hydrocortisone lotion as an anti-inflammatory and antipruritic preparation for mosquito reactions
Authors: Uy, Veronica S, MD; Gracia B. Teodosio, MD, FPDS; Ma. Teresita G. Gabriel, MD, FPDS; Mary Catherine T. Galang, MD; Mohammad Yoga A. Waskito, MD; Johannes F. Dayrit, MD, FPDS Abstract Background: Virgin coconut oil (VCO) has been reported...
Primary Cutaneous Anaplastic Large Cell Lymphoma (PC-ALCL) is a rare Non-Hodgkin lymphoma (NHL) representing approximately 9% of all cutaneous lymphomas.3 It usually manifests as a slow-growing, solitary tumor which has a tendency to regress spontaneously. However, metastasis is reported in 5-10% of cases.