Authors: Patricia Angelica Pastrana-Mabanta, MD, MBA, Ma. Jasmin J. Jamora, MD, FPDS, Mae Ramirez-Quizon MD, FPDS
Introduction: Epidermolysis Bullosa, Generalized-Severe (EBS-gen sev) is a rare genodermatosis, resulting from multiple gene mutations, characterized by marked mechanical skin fragility. It presents at birth with disseminated friction-induced blistering. Erosions heal without scarring and lesions tend to improve with age.
Case Summary: A 1-year old Filipino female presented at birth with red bumps and blisters on the distal extremities, which later spread during infancy. No history of trauma or viral infection noted. Hyperkeratosis of the palms and soles, and nail thickening developed. Skin punch biopsy revealed Subepidermal Vesicobullous Dermatitis, inflammatory, predominantly eosinophilic, supporting the diagnosis Infantile Bullous Pemphigoid. Direct immunofluorescence was negative, pointing to Epidermolysis Bullosa. Genetic Mutation Testing was done in Israel, with pending results. The patient was treated symptomatically. During follow-ups, the child continued to have blister formation but was otherwise healthy.
Conclusion: EBS-gen sev is a rare inherited disorder, with no targeted therapy, and is thus an active area of investigation.
Epidermolysis bullosa simplex, Generalized severe, Bullous eruption, Genodermatosis
Authors: Katrina Carmela M. Belen, MD, DPDS, Jasmin J.Jamora, MD, FPDS , Ma. Cecilia P. Ingente MD, DPDSAbstractBackground: Dermoscopy, a non-invasive diagnostic tool, has been proven to improve the diagnostic accuracy of vascular tumors since it can aid in...
A randomized, double-blind, comparative study on the safety and efficacy of virgin coconut (Cocos nucifera l.) oil against 1% hydrocortisone lotion as an anti-inflammatory and antipruritic preparation for mosquito reactions
Authors: Uy, Veronica S, MD; Gracia B. Teodosio, MD, FPDS; Ma. Teresita G. Gabriel, MD, FPDS; Mary Catherine T. Galang, MD; Mohammad Yoga A. Waskito, MD; Johannes F. Dayrit, MD, FPDS Abstract Background: Virgin coconut oil (VCO) has been reported...
Primary Cutaneous Anaplastic Large Cell Lymphoma (PC-ALCL) is a rare Non-Hodgkin lymphoma (NHL) representing approximately 9% of all cutaneous lymphomas.3 It usually manifests as a slow-growing, solitary tumor which has a tendency to regress spontaneously. However, metastasis is reported in 5-10% of cases.