Category: May 2017 What Lies Beneath

Telangiectasia Macularis Eruptiva Perstans in an Indian man: Correlation between clinical, dermoscopic, histopathological, and immunohistochemical findings

Cutaneous mastocytosis (CM) is characterized by accumulation of mast cells confined to the skin. Telangiectatic macularis eruptiva perstans (TMEP) is the rarest type of CM, seen in <1% of mastocytosis patients, presenting as telangiectatic patches on the trunk and upper limbs. Although mostly confined to the skin, TMEP may involve the bone marrow, lymph nodes, liver, spleen and gastrointestinal tract. Diagnosis is confirmed histopathologically by increased mast cells, dilated capillaries and venules of the dermal superficial plexus. When the number of mast cells are within normal range, special stains are utilized to highlight these cells, including Giemsa, and immunohistochemical staining for c-kit (CD117), which is involved in the pathogenesis of mastocytosis

/* ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ CUSTOM FIELD - conditionally display Abstract button ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ /* ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Conditionally display Abstract button ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ /* ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Conditionally display References button ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */

Keratoacanthoma centrifugum marginatum in brown skin: A diagnostic conundrum

Keratoacanthoma centrifugum marginatum (KCM) is an extremely rare variant of keratoacanthoma (KA) that is characterized by rapidly growing tumor with progressive peripheral expansion and central clearin. It predominantly affects white-skinned races, and affects areas with extensive exposure to UVB. We present a case of a Filipino farmer who presented with a verrucous lesion on the knee, which was eventually diagnosed histopathologically as KCM.

/* ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ CUSTOM FIELD - conditionally display Abstract button ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ /* ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Conditionally display Abstract button ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */ /* ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Conditionally display References button ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ */