Efficacy and Safety of 10% Povidone–Iodine Solution for the Treatment of Molluscum Contagiosum: A double blind, Placebo-Controlled, Randomized Clinical Trial

Authors: Marilie E. Araojo, MD, Dr. Benedicto dL. Carpio, FPDS, Dr. Eileen R. Morales, FPDS, Dr. Armelia L. Torres, FPDS

Abstract

Introduction: Molluscum contagiosum is a common viral disease of childhood presenting as small, firm, dome-shaped umbilicated papules. Treatment options include destructive therapies, immunomodulators, and antivirals.

Objectives: To determine the efficacy and safety of Topical 10 % Povidone–Iodine Solution for the Treatment of Molluscum Contagiosum.

Methods: The study is a randomized, placebo-controlled, double-blind, clinical trial using 10 % Povidone-Iodine. A total of 32 pediatric patients (2-17 years old) with Molluscum Contagiosum located on the truck and extremities were included in the study randomly assigned into two groups. Sixteen subjects were assigned to group A and B (Povidone Iodine and Placebo solution respectively). Patients were evaluated at baseline, before treatment and follow up for 4 weeks.

Results: There was no significant difference noted in the age and sex of subjects between the two groups as proven by the p values 0.87 and 0.65 respectively. The median number and size of lesions has a decreasing trend until the last follow up for the 10% Povidone Iodine solution versus the placebo treatment. Hyperpigmentation and pruritus are the noted adverse effects.

Conclusions: There is no statistical difference between the Povidone Iodine and Placebo solution. However, the number and average size of the lesions were shown to have decreasing trend until the last follow-up using the Povidone Iodine compared to placebo solution. Hence, Povidone iodine can be used as an alternative treatment for Molluscum Contagiosum.

 

Citation

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Keywords

Molluscum Contagiosum, Povidone Iodine, Efficacy

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