Authors: Maria Victoria Rosabelle M., Rovira-Suetomi,MD, Bernardita O. Policarpio, MD,FPDS, Claudine B. Yap-Silva,MD, FPDS
Abstract
Introduction: Eosinophilic Pustular Folliculitis (EPF) is a chronic cutaneous manifestation of Human Immunodeficiency Virus (HIV), which manifests as folliculo-papular lesions commonly appearing on the chest, arms, head, and neck. The associated pruritus is so intense that it has been described to be akin to scabies. Various treatment options include Antiretroviral Therapy (ART), oral antihistamines, topical corticosteroids, prednisone, isotretinoin, itraconazole, metronidazole, narrowband ultraviolet B (NBUVB), and ultraviolet A with and without psoralen in order to address the pruritus.
Case Summary:We report a case of a 31-year-old HIV-positive male patient who presented with an 8-month history of pruritic, erythematous to hyperpigmented follicular papules on the upper trunk and extremities. Skin punch biopsy revealed a moderately dense perifollicular infiltrate of numerous eosinophils and lymphocytes.
Conclusion:The patient had excellent response to NBUVB after being unresponsive to a multitude of topical and systemic medications and being on the ART for five months. Thus, NBUVB is an effective treatment option for both the resolution of lesions and pruritus among patients with HIV-EPF (Human Immunodeficiency Virus-associated Eosinophilic Pustular Folliculitis) who have failed ART and other therapies.
Citation
Rovira-Suetomi, MVR, Policarpio, B. & Yap-Silva, C. (2017). Eosinophilic pustular folliculitis in a 31-year-old Filipino male treated with narrowband ultraviolet B radiation: A case report. Journal of the Philippine Dermatological Society, 26(2), 58-60.
Keywords
eosinophilic pustular folliculitis, HIV, AIDS, NBUVB
- Nervi SJ, Schwartz RA, Dmochowski M. Eosinophilic pustular folliculitis: a 40 year retrospect. J Am Acad Dermatol. 2006 Aug 31;55(2):285-9.
- Sufyan W, Tan KB, Wong ST, Lee YS. Eosinophilic pustular folliculitis. Arch Pathol Lab Med. 2007 Oct;131(10):1598-601.
- Nomura T, Katoh M, Yamamoto Y, Miyachi Y, Kabashima K. Eosinophilic pustular folliculitis: a proposal of diagnostic and therapeutic algorithms. J Dermatol. 2016 Nov 1;43(11):1301-6.
- Human Rights Watch. . Fueling the Philippines’ HIV Epidemic: Government Barriers to Condom Use by Men Who Have Sex With Men. 2016 Dec 8. Available from: https://www.hrw.org/report/2016/12/08/fueling-philippines-hiv-epidemic/government-barriers-condom-use-men-who-have-sex.
- Chawhan SM, Bhat DM, Solanke SM. Dermatological manifestations in human immunodeficiency virus infected patients: Morphological spectrum with CD4 correlation. Indian J Sex Transm Dis. 2013 Jul;34(2):89.
- Nervi SJ, Schwartz RA, Dmochowski M. Eosinophilic pustular folliculitis: a 40 year retrospect. J Am Acad Dermatol. 2006 Aug 31;55(2):285-9.
- Toutous-Trellu L, Abraham S, Pechère M, Chavaz P, Lübbe J, Schiffer V, et al. Topical tacrolimus for effective treatment of eosinophilic folliculitis associated with human immunodeficiency virus infection. Arch Dermatol. 2005 Oct 1;141(10):1203-8.
- Kuwano Y, Watanabe R, Fujimoto M, Komine M, Asahina A, Tsukada N, et al. Treatment of HIV‐associated eosinophilic pustular folliculitis with narrow‐band UVB. Int J Dermatol. 2006 Oct 1;45(10):1265-7.
- Ellis E, Scheinfeld N. Eosinophilic Pustular Folliculitis. Am J Clin Dermatol. 2004 Jun 1;5(3):189-97.
- Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, and Wolff K, eds. Fitzpatrick’s Dermatology in General Medicine. 8th New York, NY: McGraw-Hill Companies, Inc.; 2008:2443.