Site Under Construction

Follicular mycosis fungoides: A report of 2 cases in Filipino octogenarians

Cara Lynn Marie N. Chia, MD, Johannes F. Dayrit, MD, FPDS, Christine Marie N. Chia-Acosta, MD, DPDS

Abstract

Introduction:

Folliculotropic mycosis fungoides is a rare and aggressive subtype of mycosis fungoides characterized by small to medium-sized malignant T-cells that typically infiltrate the hair follicle. It represents 4% of primary cutaneous lymphomas and less than 10% of patients with MF.

Case:

We report 2 cases of 80-year old female, who presented with a 3-year history of an erythematous plaque on the left infraorbital area and forehead, and the other with an 8-month history of multiple erythematous indurated plaques on the left cheek, left eyebrow and malar area. Clinical presentation, histopathology and immunohistochemistry findings revealed a diagnosis of folliculotropic mycosis fungoides.

Conclusion:

Folliculotropic mycosis fungoides has distinct clinical and microscopic features. Evaluation of clinical, pathologic, and immunophenotypic findings are important to identify this rare form of cutaneous T-cell lymphoma.

References

Vergote V, Wolter E, Hauben E, Busschots AM. Folliculotropic mycosis fungoides: a clinicopathological study of a series of 10 cases. J Dermatol Res Ther. 2016 April;2:022
Gomez-Diez S, Maldonado C, Fueyo A, Vazquez-Lopez F, Fresno MF, Perez-Olivia N. Folliculotropic mycosis fungoides. study of four cases. Actas Dermosifiliogr. 2007 October; 98:486-90
Lehman JS, Cook-Norris RH, Weed BR, Weenig RH, Gibson LE, Weaver AL, Pittelkow MR. Folliculotropic mycosis fungoides single-center study and systemic review. Arch Dermatol. 2010; 146 (6): 607-613
McKee P, Calonje E, Brenn T, Lazar A. McKee’s pathology of the skin. 4th ed. Elsevier Saunders. 2012; 1331-1334
Keehn CA, Belongie IP, Shistik G, Fenske NA, Glass LF. The diagnosis, staging, and treatment options for mycosis fungoides. Cancer Control. 2007 April; 14 (2): 102-109
Weedon D. Weedon’s skin pathology. 3rd ed. London: Churchill Livingstone Elsevier. 2010; 978-979
Amitay-Laish I, Feinmesser M, Ben-Amitai D, Fenig E, Sorin D, Hodak E. Unilesional folliculotropic mycosis fungoides: a unique variant of cutaneous lymphoma. JEADV. 2016; 30: 25-29
Bakar O, Seckin D, Demirkesen C, Baykal C, Buyukbabani N. Two clinically unusual cases of folliculotropic mycosis fungoides: one with and the other without syringotropism. Ann Dermatol. 2014; 26 (3): 385-391
Gordon MC, Sluzevich JC, Jambusria-Pahlajani A. Clearance of folliculotropic and tumor mycosis fungoides with topical 5% imiquimod. JAAD. 2015; 1:348-50
Yu-Hung K, Chung-Hsing C. Erythrodermic mycosis fungoides treated with low-dose methotrexate and 311 nm UV-B: a case report with 3-year follow up and literature review. Dermatologica Sinica. 2016; 34: 37-41
Trautinger F, Knobler R, Willemze R, Peris K, Stadler R, Laroche L, D’Incan M, Ranki A, Pimpinelli N, Ortiz-Romero P, Dummer R, Estrach T, Whittaker S. EORTC concensus recommendations for the treatment of mycosis fungoides/sezary syndrome. European Journal of Cancer. 2006; 42: 1014-1030
Bukhari IA. Rare variant of mycosis fungoides. Ann Saudi Med. 2006; 26 (2): 150-151