Nov 2018 Supplemental Issue Adverse Drug Reactions

Methotrexate Toxicity Presenting with Cutaneous Ulcers in a 51-Year Old Female Treated with Low-Dose Methotrexate: A Case Report

Diandra Aurora Zabala, Karen Lee Alabado, Maria Vinna Crisostomo, Michelle Sim

Methotrexate is highly effective for psoriasis vulgaris and is often used as long-term management. Well known for its side effects of myelosuppression and liver toxicity, methotrexate also induces skin ulceration, which often heralds other markers of toxicity.

Generalized bullous fixed drug eruption from vincristine and cyclophosphamide in a patient undergoing chemotherapy for gestational trophoblastic neoplasia

Felix Paolo J,. Lizarondo, MD, Charmaine Vanessa S. Chamberlin, MD, Francisca DC Roa MD, FPDS

Generalized bullous fixed drug eruption (GBFDE) is a rare presentation of fixed drug eruption. Fixed drug eruption can present with bullae but can present in a widespread distribution as GBFDE.

A Case of Steven Johnson Syndrome-Toxic Epidermal Necrolysis Overlap with Systemic Lupus Erythematosus

Leah Antoinette M. Caro-Chang, Sarah Faye V. Obbus, Claudine Yap-Silva, Eileen Liesl A. Cubillan, Georgina C. Pastorfide

We report a case of Steven Johnson Syndrome-Toxic Epidermal Necrolysis (SJS-TEN) overlap in a patient with systemic lupus erythematosus (SLE). Identified drugs were amoxicillin-clavulanic acid and ibuprofen however, connective tissue diseases such as SLE contributed to this as well.

Cotrimoxazole-induced generalized bullous fixed drug eruption mimicking stevens-johnson syndrome: a case report

Marie Len A. Camaclang, MD, Eileen Liesl A. Cubillan, MD, FPDS

Generalized bullous fixed drug eruption (GBFDE) is characterized by generalized erythema and appearance of multifocal ill-defined hyperpigmentation, and flaccid bullae which easily rupture and exhibit epidermal detachment. It may be clinically indistinguishable from stevens-johnson syndrome (SJS), especially on initial presentation.