Diandra Aurora Zabala, Karen Lee Alabado, Maria Vinna Crisostomo, Michelle Sim
Nov 2018 Supplemental Issue Adverse Drug Reactions, November 2018 Supplemental Issue
Methotrexate is highly effective for psoriasis vulgaris and is often used as long-term management. Well known for its side effects of myelosuppression and liver toxicity, methotrexate also induces skin ulceration, which often heralds other markers of toxicity.
Sri Vitayani, Ade Indriyani
Nov 2018 Supplemental Issue Adverse Drug Reactions, November 2018 Supplemental Issue
Dapsone hypersensitivity syndrome (DHS) is an allergic reaction caused by dapsone, one of the components in the WHO leprosy multidrug therapy (MDT), which usually occurs in the fourth-eighth week of the treatment.
Astri Melistri, Irene Djuardi, Idrianti Idrus, Muji Iswanty, Faridha Ilyas
Nov 2018 Supplemental Issue Adverse Drug Reactions, November 2018 Supplemental Issue
Toxic Epidermal Necrolysis (TEN) is acute mucocutaneous reaction characterized with extensive necrosis of epidermis. It is the highest grade of SJS-TEN clinical spectrum, involving necrosis of >30% of body surface area.
Felix Paolo J,. Lizarondo, MD, Charmaine Vanessa S. Chamberlin, MD, Francisca DC Roa MD, FPDS
Nov 2018 Supplemental Issue Adverse Drug Reactions, November 2018 Supplemental Issue
Generalized bullous fixed drug eruption (GBFDE) is a rare presentation of fixed drug eruption. Fixed drug eruption can present with bullae but can present in a widespread distribution as GBFDE.
Leah Antoinette M. Caro-Chang, Sarah Faye V. Obbus, Claudine Yap-Silva, Eileen Liesl A. Cubillan, Georgina C. Pastorfide
Nov 2018 Supplemental Issue Adverse Drug Reactions, November 2018 Supplemental Issue
We report a case of Steven Johnson Syndrome-Toxic Epidermal Necrolysis (SJS-TEN) overlap in a patient with systemic lupus erythematosus (SLE). Identified drugs were amoxicillin-clavulanic acid and ibuprofen however, connective tissue diseases such as SLE contributed to this as well.
Marie Len A. Camaclang, MD, Eileen Liesl A. Cubillan, MD, FPDS
Nov 2018 Supplemental Issue Adverse Drug Reactions, November 2018 Supplemental Issue
Generalized bullous fixed drug eruption (GBFDE) is characterized by generalized erythema and appearance of multifocal ill-defined hyperpigmentation, and flaccid bullae which easily rupture and exhibit epidermal detachment. It may be clinically indistinguishable from stevens-johnson syndrome (SJS), especially on initial presentation.