Nov 2018 Supplemental Issue Hair/Scalp Disorders


Alopecia areata incognito responsive to azathioprine presenting in a patient with uncontrolled iatrogenic hypothyroidism

Felix Paolo J,. Lizarondo, MD, Claudine Yap-Silva, MD, FPDS

Alopecia areata incognito is a rare variant of alopecia areata presenting as diffuse hair thinning, hence its other name diffuse alopecia areata. It usually mimics acute telogen effluvium but has the characteristic trichoscopic findings of alopecia areata.

Efficacy and safety of topical adenosine for androgenetic alopecia in adults: a systematic review

Blythe N. Ke, Ma. Lorna F. Frez

Androgenetic alopecia (AGA), also known as pattern hair loss, is the most common type of hair loss in men and women. This review aims to evaluate the efficacy and safety of a potential treatment option, topical adenosine, for androgenetic alopecia in male and female adults versus placebo and other comparators.

Acne Keloidalis Nuchae with Tufted Hair Folliculitis in a 42-year-old Male: A Case Report

Lisa Denise A. Encarnacion, MD, Dell Kristie O. Castillejos, MD FPDS, Claudine Y. Silva, MD, FPDS

Acne Keloidalis Nuchae (AKN) is a chronic disorder involving inflammation and
scarring of hair follicles with subsequent development of keloid-like papules and plaques
commonly affecting the occipital scalp. Tufted Hair Folliculitis (THF) is a rare and progressive
inflammatory condition of the scalp characterized by peculiar tufting of hair. Several authors
suggest THF is a secondary phenomenon occurring in inflammatory scalp disorders, including
Dissecting Cellulitis, Acne Keloidalis Nuchae, and Folliculitis Decalvans.

Efficacy of azathioprine for alopecia areata: a systematic review of observational and interventional studies

Val Constantine S. Cua, Juan Paolo David S. Villena, Felix Paolo J. Lizarondo, Claudine Y. Silva

Alopecia areata is postulated to be an autoimmune hair disorder characterized by patches of hair loss. Corticosteroids have been utilized to treat the said disorder, but efficacy has proven to be subpar when applied to severe and extensive variants such as alopecia areata totalis, alopecia areata universalis, and ophiasis. Prolonged steroid therapy leads to side effects such as skin atrophy, weight gain, Cushing syndrome, immunosuppression, and hypothalamic-pituitary-adrenal axis suppression, while discontinuation of the treatment leads to high relapse rate. There is a need for alternative treatment modalities with better safety profile and sustained treatment response to address this dilemma.