Nov 2018 Supplemental Issue T-Cell Lymphomas/Pseudolymphomas


Primary Cutaneous CD 30-Positive Anaplastic Large Cell Lymphoma presenting as ulcerated nodules in a 50-year old woman

Elisabeth Ryan, MD, Mohammad Yoga Adi Waskito, MD, Johannes F. Dayrit, MD, FPDS

Anaplastic large-cell lymphoma (ALCL) is a CD30-positive T-cell lymphoma, a rare subtype of Cutaneous T-cell lymphoma (CTCL). It is classified into primary cutaneous ALCL and systemic ALCL subtypes. Primary cutaneous CD30-positive T-cell lymphoma account for 25% of all cutaneous T-cell lymphomas (CTCL).

Mimicry at its Finest: A case of folliculotropic mycosis fungoides with secondary xanthomatization in a Filipino male

Sarah Faye V. Obbus, Eileen Liesl A. Cubillan

Folliculotropic mycosis fungoides (MF) is an uncommon and aggressive variant of MF. It usually takes months to years before this condition is diagnosed because of its nonspecific presentation. Secondary xanthomatization, on the other hand, has been reported to arise from different inflammatory skin diseases including mycosis fungoides.

CD 30+ anaplastic large cell lymphoma with regional lymph node metastases in a 59-year old male

Jo Faustine Q. Manzano, MD, Maricar Pamela Lacuesta-Gutierrez, MD, FPDS

Cutaneous anaplastic large cell lymphoma (CALCL) has an estimated incidence of 0.1 to 0.2 per 100,000. This condition usually occurs as localized lesions in adults with extremities, head and buttocks as most common presenting sites. It is characterized by large tumor cells, majority which express the CD30 antigen.

Mycosis fungoides mimicking Squamous cell carcinoma in a 38-year old female

Maynie Bambi D. Lugasan, Camille Joyce J. Crisostomo, Karen Lee Alabado-Laurel

Mycosis fungoides is the most common among the cutaneous T-cell lymphomas. It typically starts either as a patch or plaque and may evolve into a tumor which may spontaneously ulcerate. We present a case of mycosis fungoides mimicking squamous cell carcinoma in a 38-year old female.

A 17-year old Filipino successfully treated with narrowband UVB for lymphomatoid papulosis and limited cutaneous systemic sclerosis

Diana Marie M. Lazaro-Nisce, MD, Maria Jasmin J. Jamora, MD, FPDS

Lymphomatoid papulosis (LyP) is a recurrent, self-healing papulonodular skin eruption, belonging to the group of cutaneous CD30+ lymphoproliferative disorders. It is rare worldwide and in the Philippines with only 11 cases recorded from 2011- 2018. Here we describe a case of LyP who was later diagnosed with limited cutaneous systemic sclerosis (lcSSc), an autoimmune inflammatory condition where the skin becomes hard and thickened and the internal organs develop fibrosis and vascular abnormalities. Only 10 cases of this have been recorded from 2011-2018 in the PDS His.

NB-UVB phototherapy for a 70-year-old Filipino male with concomitant nonsegmental vitiligo and mycosis fungoides in patch-plaque stage, a case report

Stephanie Manuella Christianto MD, Benedicto dL. Carpio MD, FPDS, Eileen Regalado-Morales MD, FPDS, Armelia Andrea Lapitan-Torres MD, FPDS, Ma. May Jasmin Yason MD, FPDS, Amelita Tanglao-De Guzman MD, FPDS

Mycosis Fungoides is a peripheral T-cell lymphoma caused by skin-homing CD4+ T cells which may progress to involve the lymph nodes and viscera. It is uncommon among East Asians. Vitiligo is a chronic pigmentary disorder due to progressive autoimmune mediated melanocytic destruction. NB-UVB phototherapy is an effective treatment modality for both MF and vitiligo. However, the two conditions coexisting makes it complicated to determine effective dose of NB-UVB.