Site Under Construction

Prevalence of Vitamin D insufficiency and deficiency among seborrheic dermatitis patients: a cross- sectional study at Makati Medical Center

Reagan Grey T. Reyes, MD, DPDS, Ma. Lourdes Aragon – De Veyra, MD, FPDS



Seborrheic dermatitis is a chronic and recurrent inflammatory dermatosis affecting different age groups with a prevalence rate of 1–5% among Asian adults. Due to its immune-modulatory and anti-inflammatory properties, vitamin D has been correlated with inflammatory dermatoses such as seborrheic dermatitis.



To determine the prevalence of vitamin D insufficiency, deficiency and severe deficiency among Filipino adult patients with moderate to severe seborrheic dermatitis.



A single-center, analytical, cross-sectional study at Makati Medical Center, which included Filipino patients aged 18–60 years, diagnosed with moderate-to-severe seborrheic dermatitis based on Investigator’s Static Global Assessment (ISGA) with serum vitamin D levels classified as normal, insufficient, deficient and severely deficient.



We included 61 patients, 5 patients (8%) of whom presented with normal Vitamin D levels. Twenty-one patients (34%) presented with vitamin D insufficiency, 32 patients (52%) presented with vitamin D deficiency, while 3 patients (5%) presented with severe deficiency. Vitamin D insufficiency and deficiency were more prevalent among patients in the younger age group (p = 0.001), with predominant scalp lesions (p = 0.006), and those who are single (p = 0.015). There was no statistically significant difference in the prevalence of vitamin D insufficiency and/or deficiency based on seborrheic dermatitis severity as per ISGA scale (p = 0.126).



Seborrheic dermatitis in Filipinos has been associated with vitamin D insufficiency, deficiency and severe deficiency. The prevalence of vitamin D deficiency is seen in almost half of patients while vitamin D insufficiency is seen in almost one-third of patients with seborrheic dermatitis. While topical and oral medications have been the treatment of choice for seborrheic dermatitis, the role of oral vitamin D supplementation as adjunct treatment may be studied.


  1. Cheong W, Yeung C, Torsekar R, Suh D, Ungpakorn R, Widaty S, et al. Treatment of seborrheic dermatitis in Asia: a consensus guide. Skin Appendage Disord. 2015;1:187-96. DOI: 10.1159/000444682.
  2. Clark G, Pope S, Jaboori K. Diagnosis and treatment of seborrheic dermatitis. American Academy of Family Physicians. 2015;91(3):185-90.
  3. Valia RG. Etiopathogenesis of seborrheic dermatitis. Indian J Dermatol Venereol Leprol. July-August 2006;72(4):253-5. DOI: 10.4103/0378-6323.26711.
  4. Wat H, Dytoc M. Off-label uses of topical Vitamin D in dermatology: a systematic review. J Cutan Med Surg. March-April 2014;18(2):91-108. DOI: 10.2310/7750.2013.13109.
  5. Shahriari M, Kerr P, Slade K, Grant-Kels J. Vitamin D and the skin. Elsevier Clinics in Dermatology. November-December 2010;28(6):663-8. DOI:
  6. Dimitrova J. Study of the level of 25-hydroxyvitamin D in patients with seborrheic dermatitis. Varna Medical University Press Journals. March 2013. DOI: 10.14748/sum.v45i1.345.
  7. Tanchee-Ngo MJ, M ercado-Asis LB. S erum 25 hydroxy v itamin D [25(OH) D] l evels a mong a dmitted F ilipino e lderly p atients. Philipp J I ntern Med. July 2013.
  8. Mostafa W, Hegazy R. Vitamin D and the skin: focus on a complex relationship: a review. J Adv Res. Nov 2015:6(6):793-804. DOI: 10.1016/j.jare.2014.01.011.
  9. Palmer D. Vitamin D and the development of atopic eczema. J Clin Med. May 2015:4(5):1036-50. DOI: 10.3390/jcm4051036.
  10. Woo Y, Jung K, Koo D, Lee J. Vitamin D as a marker for disease severity in chronic urticaria and it’s possible role in pathogenesis. Ann Dermatology. 2015; 27(4):423-30. DOI: 10.5021/ad.2015.27.4.423.
  11. Borzutzky A, Camargo C. Role of vitamin D in the pathogenesis and treatment of atopic dermatitis. Expert Rev Clin Immunology. Aug 2013:
    0(8):751-60. DOI: 10.1586/1744666X.2013.816493.
  12. Rahimi S, Nemati N, Shafaei-Tonekaboni S. Serum levels of 25-hydroxyvitamin D in patients with seborrheic dermatitis: a case-control study. Hi Dani Dermatology Research and Practice. February 2021: 6623271. DOI:
  13. Byung I, Dawson T. The role of sebaceous gland activity and scalp microfloral metabolism in the etiology of seborrheic dermatitis and dandruff. J Investig Dermatol Symp Proc. 2005;10:194-6. DOI: 10.1111/j.1087-0024.2005.10104.x.

REquesting Permission

Prevalence of Vitamin D insufficiency and deficiency among seborrheic dermatitis patients: a cross- sectional study at Makati Medical Center