Authors: Terese Monette O. Aquino, MD, Ma. Jasmin J. Jamora, MD, FPDS


Introduction: Recurrent aphthous stomatitis (RAS) is a common oral ailment characterized by frequent attacks of painful oral ulcers that heal spontaneously. Severe form of RAS is known as complex aphthosis (CA) which is an unfamiliar term for many. Characterized by almost always constant presence of ≥3 painful aphthae alone, with or without genital aphthosis AND exclusion of Behcet disease (BD). CA may be a reactive condition; thus, diagnosis is based on exclusion.

Case Summary: Herein, we present an eight-year case of a primary idiopathic CA; work-up and examination were done to exclude BD and other diseases. Colchicine and montelukast were preferred as alternatives for systemic glucocorticoids which showed favorable control of CA observed in 5 months.

Conclusion: Emphasis to rule out BD is important since it’s a multisystem disease that requires different management. Management of primary CA varies, but most patients warrant the use ofsystemic agents because of its intractability. Multiple agents have been studied and proven to control CA; because of prolonged treatment, systemic medications with least side effects are preferred. Montelukast was shown to provide same level of disease control compared with colchicine as seen in this case. It inhibits leukotriene receptor, neutrophils and blocks immune-complex mediated hypersensitivity, thereby interrupting development of RAS. It is unclear until now if CA predisposes a patient to develop BD. Therefore, it is advocated to monitor patient for progression since It may precede the diagnosis for several years.





Complex Aphthosis, Recurrent Aphthous Stomatitis, Recurrent Aphthous Ulcers, Aphthous ulcers, Behcet Disease, Atypical Behcet Disease

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