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Scleromyxedema in a 47-year-old female treated with colchicine and topical steroids

Authors: Eunice Kaye M. Rayos-Lopez, MD, Mary Catherine T. Galang, MD, DPDS,  Dr. Ricky H. Hipolito, MD, DPDS, Ma. Teresita G. Gabriel, MD, FPDS


Introduction: Scleromyxedema is a rare skin disorder characterized by fibroblast proliferation and mucin deposition in the dermis, in the absence of thyroid disease. The precise mechanisms whereby increased fibroblast activity results in mucin deposition remain to be defined, but the etiology of the disorder still remains to be unknown.

Case Summary: We report a rare case of a 47-year-old female with a three-year history of multiple erythematous to light brown, firm, waxy, slightly pruritic papules and plaques on the earlobes, nose, buttocks and extremities. Dermatologic examination showed multiple 2-3mm firm, waxy, closely-spaced papules and plaques symmetrically distributed on the earlobes, nose, arms, buttocks, extending into thighs and knees. Routine laboratory tests and thyroid function test results were within the normal range. Skin punch biopsy was done on the right arm and histopathologic results were consistent with diagnosis of papular mucinosis. Patient was treated with topical steroids and colchicine with significant improvement of the lesions.

Conclusion: Scleromyxedema is a rare, chronic and unpredictable disease with no specific definitive treatment. Most commonly used therapies are intravenous and immunogloblulin (IVIg) and systemic steroids. Few data are available on more cost-effective treatment options. Colchicine should be further explored as cost-effective and safer alternative treatment in the management of this disease.


Lopez, E., Galang, MC., Hipolito, R.& Gabriel, MT. (2017). Scleromyxedema in a 47-year-old female treated with colchicine and topical steroids. Journal of the Philippine Dermatological Society, 26(2), 67-70.



Scleromyxedema, Papular mucinosis, Lichen myxedematosus, Colchicine

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Scleromyxedema in a 47-year-old female treated with colchicine and topical steroids