(Last Updated On: March 23, 2020)
Authors: Cynthia Angela Karim, MD, Johannes F. Dayrit, MD, FPDS, Vicky Wee Eng Binas, MD, FPPS


Hyper -immunoglobulin E syndrome (HIES) is a rare immunodeficiency disorder which appears early in life with recurrent staphylococcal and candida infections, pneumonias, lymphadenitis, and eczematous skin. Serum IgE concentrations are extremely high in patients with HIES (> 2000 IU/ml). Although rare, squamous cell carcinoma has been reported in HIES, perhaps due to chronic infection and irritation of the epidermis.



Hyperimmunoglobulin, Squamous cell, HIES


1. Fuleihan RL, Paller AS. Genetic Immunodeficiency Diease. In: Goldsmith .L.A, et al, editors. Fitzpatrick’s Dermatology in General Medicine. 9th ed. Vol 2. New York : McGraw-Hill; 2019; p:2413-16.

2. Sasihuseyinoglu AS, Yilmaz M, Altintas DU. Et al . Squamous Cell Carcinoma With Hyper-IgE Syndrome : A Case Report. J Pediatr Hematol Oncol. 2018;40(6):380-382. doi: 10.1097/MPH.0000000000000954

3. Yanofsky VR, Mercer SE, Phelps RG. Histopathological variants of cutaneous squamous cell carcinoma : A review. J Skin Cancer. 2011;1-13. doi:10.1155/2011/210813

4. Potenza C, Bernardini N, Balduzzi V. Et al. A review of the literature of surgical and nonsurgical treatments of invansive squamous cell carcinoma. Biomed Research International. 2018;1-9. doi.org/10.1155/2018/9489163

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