(Last Updated On: March 23, 2020)
Authors: Cynthia Angela Karim, MD, Johannes F. Dayrit, MD, FPDS, Vicky Wee Eng Binas, MD, FPPS

Abstract

Hyper -immunoglobulin E syndrome (HIES) is a rare immunodeficiency disorder which appears early in life with recurrent staphylococcal and candida infections, pneumonias, lymphadenitis, and eczematous skin. Serum IgE concentrations are extremely high in patients with HIES (> 2000 IU/ml). Although rare, squamous cell carcinoma has been reported in HIES, perhaps due to chronic infection and irritation of the epidermis.

 

Keywords

Hyperimmunoglobulin, Squamous cell, HIES

 

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2. Sasihuseyinoglu AS, Yilmaz M, Altintas DU. Et al . Squamous Cell Carcinoma With Hyper-IgE Syndrome : A Case Report. J Pediatr Hematol Oncol. 2018;40(6):380-382. doi: 10.1097/MPH.0000000000000954

3. Yanofsky VR, Mercer SE, Phelps RG. Histopathological variants of cutaneous squamous cell carcinoma : A review. J Skin Cancer. 2011;1-13. doi:10.1155/2011/210813

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