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Telangiectasia Macularis Eruptiva Perstans in an Indian man: Correlation between clinical, dermoscopic, histopathological, and immunohistochemical findings

Authors: Lunardi Bintanjoyo, MD;Johannes F. Dayrit, MD, FPDS;Ma. Teresita G. Gabriel, MD, FPDS and Ciara Mae H. Dela Cruz, MD


Telangiectatic macularis eruptiva perstans (TMEP) is the rarest type of cutaneous mastocytosis (CM). It presents on the trunk and upper limbs as telangiectatic macules and patches due to concentrated mast cells degranulation which are identified as reticular vascular pattern in dermoscopy. Histopathologically, they correlate with dilated capillaries and venules of the dermal superficial plexus surrounded by increased mast cells’ numbers. Giemsa and immunohistochemical stain CD117 highlight mast cells when the routine histopathology shows mild changes. Management of CM, aiming to avoid and treat symptoms of mast cell mediator release, includes systemic anthistamines as first line agents. We report a case of a 52-year-old Indian man with clinical, dermoscopic, histopathologic and immunohistochemical findings of TMEP in which intensity of erythema decreased after one month of treatment with Ketotifen 2 mg once every evening and Bilastine 20 mg once every morning.



Bintanjoyo, L, Dela Cruz, CM, Dayrit, J & Gabriel, MT. (2017). Telangiectasia macularis eruptiva perstans in an Indian man: Correlation between clinical, dermoscopic, histopathological, and immunohistochemical findings. Journal of the Philippine Dermatological Society, 26(1), 88-90.



Telangiectatic macularis eruptive perstans, dermoscopy, Giemsa, CD117, antihistamines


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Telangiectasia Macularis Eruptiva Perstans in an Indian man: Correlation between clinical, dermoscopic, histopathological, and immunohistochemical findings