Authors: Terese Monette O. Aquino, MD, Karla Angela P. Cuenca-Luchnagco, MD, DPDS, Vermen M. Verallo-Rowell, MD, FPDS, Elizabeth V. Sanchez, MD, FPDS
Background: Novel agents with good safety profiles are needed in the management of chronic kidney disease – associated pruritus (CKD-AP). This study aims to assess the efficacy and safety of topical gabapentin in the treatment of CKD-AP.
Methods: This is a randomized, double-blind, placebo-controlled study. The inclusion criteria were: (1) patients on hemodialysis for at least eight weeks, and (2) baseline visual analog scale (VAS) pruritus score ≥ 5. Patients were randomized to either, (1) experimental (topical gabapentin) or (2) control group (placebo). Content of gabapentin capsules were dissolved in water and compounded to (PG+PEG) to yield 6% concentration. Primary endpoint was change in pruritus scores (VAS) from baseline after one and two weeks of once daily application.
Results: A total of thirty patients (fifteen per group) were included in the analysis. In the experimental group, mean pruritus scores significantly decreased at one week (mean score 2.7; range 0-5; p<0.001) and two weeks (mean score 1.3, range 0-5; p<0.001) from the baseline (mean score 5.9; range 5-8). Change in pruritus scores after one week was not significantly different (p=0.8) between experimental and control groups. Change in pruritus scores after two weeks were significantly higher (p=0.01) in the experimental group (mean change -4.6; range 0-7) versus the control group (mean change -2.6; range -1-5). There were no reported adverse events.
Conclusion: Compared to placebo, decreased VAS pruritus scores was seen after 2 weeks of topical 6% gabapentin use with no reports of adverse events.
Topical gabapentin, Uremic pruritus, Chronic kidney disease, hemodialysis, Gabapentin cream
Authors: Katrina Carmela M. Belen, MD, DPDS, Jasmin J.Jamora, MD, FPDS , Ma. Cecilia P. Ingente MD, DPDSAbstractBackground: Dermoscopy, a non-invasive diagnostic tool, has been proven to improve the diagnostic accuracy of vascular tumors since it can aid in...
A randomized, double-blind, comparative study on the safety and efficacy of virgin coconut (Cocos nucifera l.) oil against 1% hydrocortisone lotion as an anti-inflammatory and antipruritic preparation for mosquito reactions
Authors: Uy, Veronica S, MD; Gracia B. Teodosio, MD, FPDS; Ma. Teresita G. Gabriel, MD, FPDS; Mary Catherine T. Galang, MD; Mohammad Yoga A. Waskito, MD; Johannes F. Dayrit, MD, FPDS Abstract Background: Virgin coconut oil (VCO) has been reported...
Primary Cutaneous Anaplastic Large Cell Lymphoma (PC-ALCL) is a rare Non-Hodgkin lymphoma (NHL) representing approximately 9% of all cutaneous lymphomas.3 It usually manifests as a slow-growing, solitary tumor which has a tendency to regress spontaneously. However, metastasis is reported in 5-10% of cases.