Toxic Epidermal Necrolysis in Patient with Malignant Lymphoma

Authors: Astri Melistri, Irene Djuardi, Idrianti Idrus, Muji Iswanty, Faridha Ilyas

Abstract

Introduction: Toxic Epidermal Necrolysis (TEN) is acute mucocutaneous reaction characterized with extensive necrosis of epidermis. It is the highest grade of SJS-TEN clinical spectrum, involving necrosis of >30% of body surface area. It is also associated with mucosal membrane. The etiology and risk factor for adult are drug use and malignancy while the etiology for children is infection.

Case Summary: Reported one case of TEN in a woman, 40 years old, comes with chief complain exfoliated skin since 3 days ago and skin disorder that arises in the form of generalized blistering and macular erythema, there is erosion of the lips and conjunctivitis. The patient have history of malignant lymphoma since 5 years ago. The patient respond well to supportive therapy and systemic corticosteroid.

Conclusion: The diagnosis is made based on history, clinical features, laboratory examinations, and skin biopsy. Malignancy is known to be associated with an increased mortality rate in patients with TEN. However, risk factors contributing to the poor prognosis of patients with TEN with malignancies remain undefined.

 

Citation

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Keywords

corticosteroid, malignant, toxic epidermal necrolysis

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