Site Under Construction

Widespread lichen planus pigmentosus in a 32-year-old Filipino male treated with low dose isotretinoin and topical tacrolimus

Nel Muriel B. Lee, MD, Heirich Fevrier P. Manalili, MD, Johannes F. Dayrit, MD, FPDS

Abstract

Introduction

Lichen Planus Pigmentosus (LPP) is a pigmentary disorder of unknown etiology, presenting with diffuse hyperpigmentation in sun-exposed areas.

Case report

We report a case of a 32-year-old healthy male with widespread lichen planus pigmentosus, treated with clobetasol dipropionate 0.05% ointment, tacrolimus 0.1% ointment, and lowdose isotretinoin (0.1 to 0.2 mkd) showing a decrease in the progression and hyperpigmentation of patches and plaques after six months.

Conclusion

Based on our case and recent studies, low-dose oral isotretinoin, in combination with topical tacrolimus and topical corticosteroids, may show promising outcomes in treating cases of widespread lichen planus pigmentosus.

References

Rodrigues, M, Pandya, AG. Hypermelanoses. In: Sewon, K, Amagai, M, Bruckner, AL, Enk, AH, Margolis, DJ, McMichael, AJ, Orringer, JS, eds.
Fitzpatrick’s Dermatology in General Medicine. 2019;9:1385 – 1386.
Robles-Méndez JC, Rizo-Frías P, Herz-Ruelas ME, Pandya AG, Ocampo Candiani J. Lichen planus pigmentosus and its variants: review and
update. Int J Dermatol. 2018;57(5):505-514.
Muthu SK, Narang T, Saikia UN, Kanwar AJ, Parsad D, Dogra S. Lowdose oral isotretinoin therapy in lichen planus pigmentosus: an open-label non-randomized prospective pilot study. Int J Dermatol. 2016;55(9):1048-1054.
Mahajan VK, Chauhan PS, Mehta KS, Sharma AL. Erythema Dyschromicum Perstans: Response to Topical Tacrolimus. Indian Journal of Dermatology. 2015 Sep-Oct;60(5):525.

Widespread lichen planus pigmentosus in a 32-year-old Filipino male treated with low dose isotretinoin and topical tacrolimus

Nel Muriel B. Lee, MD, Heirich Fevrier P. Manalili, MD, Johannes F. Dayrit, MD, FPDS

Abstract

References

The importance of dermoscopy in the diagnosis of lentigo maligna melanoma in a 58-year-old Filipino: a case report

Childhood bullous pemphigoid: A case report

A novel mutation in the EDA gene in a Filipino family with X-linked hypohidrotic ectodermal dysplasia

REquesting Permission

Widespread lichen planus pigmentosus in a 32-year-old Filipino male treated with low dose isotretinoin and topical tacrolimus